SiN-EV has joined the European initiative MOVE (MObility for Vesicles research in Europe), established to foster collaboration between the members of different European EV Societies and Networks. The current project of the initiative is MOVE European Mobility Fellowship, which enables short-term (1-3 months) visits of early-stage scientists – technicians, doctoral students, and young postdoctoral students – involved in the research of extracellular vesicles to other European laboratories.
This week, #EVCLub is a collaboration with the Slovenian EV Network (SiN-EV): Mateja Manček Keber presents “Synergy between 15-lipoxygenase and secreted PLA2 promotes inflammation by formation of TLR4 agonists from EVs” https://www.pnas.org/content/117/41/25679.
The Meeting will be accompanied by an Education Day, planned to educate new researchers and to assist with updating those already working in this field on topics of: EV preparation and characterization; EV biogenesis, targeting, uptake; EV application as biomarkers and therapeutics; and Advances and trends in EVs. Education Day will take place on Wednesday 25th May 2022 in the same venue as the main conference. ISEV2022 Conference Attendees can add Education Day at the registration, there is also a possibility to attend the Education Day only.
Traditionally, Socratic lectures feature excellent science donated by top experts in the field to the students, and promote work of young researchers.
This year, the plenary lecture will be given by prof. Antonella Bongiovanni from Palermo, Italy. The title of her lecture is “Green bioparticles for cross-kingdom communication: a drug delivery platform designed by nature”. Plenary lecture will be followed by 7 parallel scientific sections. After the parallel sections, a special section where science meets art will be presented.
Please see the programme of the symposium at the homepage of the Laboratory of Clinical Biophysics www.lkbf.si.
Posters will be available at the site of the Laboratory of Clinical Biophysics. You can still submit a poster. Also, contributions to the Proceedings (Invited lectures, Scientific contributions and Reflections) are welcomed until the end of 2021. Further instructions and the templates for posters and proceeding contributions: http://www.lkbf.si/about.
In the evening, organ concert will take place LIVE at the Francescan Church of the Assumption, Prešernov trg, at 20.00.
The organist Roberta Schmid from Naples, Italy will present a program: J.S. Bach Choral Ich ruf zu dir, Herr Jesu Christ BWV 639 J.S. Bach Toccata and Fugue in D minor BWV 565 J. Pachelbel Ciacona in F minor P. A. Yon Toccatina for flute E. Gigout Toccata in B minor M. Mussorgsky Old castle (from Pictures at an exhibition – trancription of J. Guillou) J.G. Rheinberger Passacaglia L. Boellmann Suite Gothique op.25: Introduction-Choral, Menuet Gothique, Prière a Notre Dame, Toccata
Location: Tuscany, Renaissance Tuscany il Ciocco Resort (in person) Dates: 20th-22nd of September 2021 Abstract deadline: 22nd of June 2021 Registration (including accommodation, for members of any European EV society): early registration: 30th June 2021 (junior – 300 EUR, senior 450 EUR) regular registration: 30th July 2021 (junior – 400 EUR, senior 600 EUR) More information: https://evitasociety.it/symposium/
Lepo vabljeni na 1. seminar mreže SiN-EV, ki bo potekal v četrtek, 15. aprila, ob 14h. V okviru seminarjev bodo člani SiN-EV predstavili svoje delo ali izpostavili vidnejše objavljene raziskave iz področja zunajceličnih veziklov.
Program: 14.00 – 14.20 Vpliv hormona gastrina na izločanje zunajceličnih veziklov iz celične linije raka želodca Pia Pužar Dominkuš; Medicinski Center za Molekularno Biologijo, Inštitut za Biokemijo in Molekularno Genetiko, UL Medicinska fakulteta
14.20 – 14.40 Karakterizacija majhnih zunajceličnih veziklov pri bolnikih z antifosfolipidnim sindromom Ula Štok; Fakulteta za Farmacijo, Univerza v Ljubljani ter Klinični oddelek za revmatologijo, Univerzitetni Klinični Center Ljubljana
14.40 – 15.00 Analiza miR-9-5p, miR-124-3p, miR-21-5p, miR-138-5p in miR-1-3p in njihovih tarčnih genov v glioblastomskih celičnih linijah in majhnih zunajceličnih veziklih Alja Zottel; Medicinski Center za Molekularno Biologijo, Inštitut za Biokemijo in Molekularno Genetiko, UL Medicinska fakulteta
My name is Alja Zottel and I am postdoc researcher in prof. Komel lab at the Medical Centre for Molecular Biology, Institute of Biochemistry and Molecular Genetics, UL MF. I am working in the field of exosomes in glioblastoma, especially exosomes as a delivery system. Glioblastoma, the most common primary brain tumor, is one of the deadliest cancers. It is characterized by highly immunosuppressive nature that significantly contributes to the malignancy of the disease. Therefore, I was excited to read more about the role of exosomes in glioblastoma immunosuppression in the manuscript by Azambuja et al., recently published in Neuro-Oncology Advances (https://doi.org/10.1093/noajnl/vdaa056).
The authors showed that exosomes carry several inhibitory proteins, such as FasL, TRAIL, CTLA-4, CD39 and CD73. In vitro, exosomes suppressed the activity of different immune cells and were able to polarize M1 macrophages towards immunosuppressive M2 phenotype by modulating NF-κB pathway. The scientists also examined the effect of exosomes in vivo and showed they decreased the number of M1 macrophages and increased the number of M2 macrophages in mice. The results overall illustrate that glioblastoma-derived exosomes stimulate immunosuppression of the tumor.
All are invited to attend ISEV2021 Annual Meeting, which will happen virtually from 18th-21st May2021. Sessions and topics of the Meeting include: EV biomarkers; EV-based therapeutics; EVs of specific cells, organs, diseases, and organisms; Fundamental biology and function of EVs; Technologies and Methods.
The Meeting will be accompanied by an Education Day, where lecturers present the overview of the chosen EV-subfield. This year’s topics of the Education Day include: Isolation & Characterization of EVs; Methodologies for studying EV biogenesis&fate; Specific Methodologies applied to biofluid and specific organisms; Therapeutic and diagnostic use of EVs. Education Day will take place on Wednesday 12th May. ISEV2021 Full Conference Attendees will have full access to Education Day, there is also a possibility to attend the Education Day only.
Infectious Diseases and Extracellular Vesicles: an ISEV Meeting will be held virtually January 25-28, 2021. Sessions and topics include EVs and COVID-19, EVs and viruses, non-viral infectious diseases, and methods and technologies in the study of EVs in infectious diseases.