EVClub: Inflammation, EVs, and TLR4 agonists

This week, #EVCLub is a collaboration with the Slovenian EV Network (SiN-EV):
Mateja Manček Keber presents “Synergy between 15-lipoxygenase and secreted PLA2 promotes inflammation by formation of TLR4 agonists from EVs” https://www.pnas.org/content/117/41/25679.

Login Wednesday, Feb 23, 12 noon EST/18.00 CET/4 AM AEDT (Feb 24) here: https://jhjhm.zoom.us/j/99677696469?pwd=NXUvSDlMSW9tVnc5MmM4ZTdGWndYQT09.

Metka Lenassi will also introduce SiN-EV.

ISEV2022 Annual Meeting

All are invited to attend 11th International Society for Extracellular Vesicles (ISEV2022) Annual Meeting, which will happen live from 26th-29st May 2022 in Lyon, France.

Sessions and topics of the Meeting include: Biomarkers, Therapeutics, Physiology and pathology, Fundamental biology, Technologies and Methods, Science and communication.

At the moment Abstract Submission site is opened and will close on January 7th 2022. More information: https://www.eventscribe.net/2022/ISEV2022/aaStatic.asp?SFP=U0VWWlRUQVlAODg3OEBBYnN0cmFjdHM.

You can register for the Meeting here: https://www.eventscribe.net/2022/ISEV2022/aaStatic.asp?SFP=RkNNUlRQRUxAOTQ0MkBSZWdpc3RyYXRpb24. Early registration ends on February 15th 2022.

The Meeting will be accompanied by an Education Day, planned to educate new researchers and to assist with updating those already working in this field on topics of: EV preparation and characterization; EV biogenesis, targeting, uptake; EV application as biomarkers and therapeutics; and Advances and trends in EVs. Education Day will take place on Wednesday 25th May 2022 in the same venue as the main conference. ISEV2022 Conference Attendees can add Education Day at the registration, there is also a possibility to attend the Education Day only.

More information is available at the Meeting website: https://www.eventscribe.net/2022/ISEV2022/.

After two virtual meetings, come and meet in person!

6th International symposium Socratic lectures

All are kindly invited to attend 6th International symposium Socratic lectures, which will happen virtually on Saturday, 11th December 2021 (from 10.00 EST – to 15.00 EST).

Link: https://uni-lj-si.zoom.us/j/99847145540

Traditionally, Socratic lectures feature excellent science donated by top experts in the field to the students, and promote work of young researchers.

This year, the plenary lecture will be given by prof. Antonella Bongiovanni from Palermo, Italy. The title of her lecture is “Green bioparticles for cross-kingdom communication: a drug delivery platform designed by nature”.
Plenary lecture will be followed by 7 parallel scientific sections. After the parallel sections, a special section where science meets art will be presented.

Please see the programme of the symposium at the homepage of the Laboratory of Clinical Biophysics www.lkbf.si.

Posters will be available at the site of the Laboratory of Clinical Biophysics.
You can still submit a poster. Also, contributions to the Proceedings (Invited lectures, Scientific contributions and Reflections) are welcomed until the end of 2021. Further instructions and the templates for posters and proceeding contributions: http://www.lkbf.si/about.

In the evening, organ concert will take place LIVE at the Francescan Church of the Assumption, Prešernov trg, at 20.00.

The organist Roberta Schmid from Naples, Italy will present a program:
J.S. Bach Choral Ich ruf zu dir, Herr Jesu Christ BWV 639
J.S. Bach Toccata and Fugue in D minor BWV 565
J. Pachelbel Ciacona in F minor
P. A. Yon Toccatina for flute
E. Gigout Toccata in B minor
M. Mussorgsky Old castle (from Pictures at an exhibition – trancription of J. Guillou)
J.G. Rheinberger Passacaglia
L. Boellmann Suite Gothique op.25: Introduction-Choral, Menuet Gothique, Prière a Notre Dame, Toccata

First Meeting of the Portuguese Network on Extracellular Vesicles (PNEV)

Location: i3S, Porto, Portugal
Dates: 13th-14th of September 2021
early registration: 23rd July 2021 (students 60 EUR, others 120 EUR)
regular registration: 1st September 2021 (students 100 EUR, others 240 EUR)

The meeting is organized in four sessions: I) Methods for EVs isolation and characterization; II) EVs in infection and immunity; III) EVs in tissue repair; and IV) EVs in cancer.

More information: https://www.i3s.up.pt/event.php?v=178

EVIta Symposium: 2nd annual meeting of Italian Society of Extracellular Vesicles

Location: Tuscany, Renaissance Tuscany il Ciocco Resort (in person)
Dates: 20th-22nd of September 2021
Abstract deadline: 22nd of June 2021
Registration (including accommodation, for members of any European EV society):
early registration: 30th June 2021 (junior – 300 EUR, senior 450 EUR)
regular registration: 30th July 2021 (junior – 400 EUR, senior 600 EUR)
More information: https://evitasociety.it/symposium/

Seminarji mreže SiN-EV

Lepo vabljeni na 1. seminar mreže SiN-EV, ki bo potekal v četrtek, 15. aprila, ob 14h. V okviru seminarjev bodo člani SiN-EV predstavili svoje delo ali izpostavili vidnejše objavljene raziskave iz področja zunajceličnih veziklov.

Seminar bo organiziran preko orodja Webex, do katerega lahko dostopate preko spodnje povezave:
Meeting number (access code): 121 548 0267
Meeting password: 5Ym6CPTPuM6

14.00 – 14.20      Vpliv hormona gastrina na izločanje zunajceličnih veziklov iz celične linije raka želodca
Pia Pužar Dominkuš; Medicinski Center za Molekularno Biologijo, Inštitut za Biokemijo in Molekularno Genetiko, UL Medicinska fakulteta

14.20 – 14.40      Karakterizacija majhnih zunajceličnih veziklov pri bolnikih z antifosfolipidnim sindromom
Ula Štok; Fakulteta za Farmacijo, Univerza v Ljubljani ter Klinični oddelek za revmatologijo, Univerzitetni Klinični Center Ljubljana

14.40 – 15.00      Analiza miR-9-5p, miR-124-3p, miR-21-5p, miR-138-5p in miR-1-3p in njihovih tarčnih genov v glioblastomskih celičnih linijah in majhnih zunajceličnih veziklih
Alja Zottel; Medicinski Center za Molekularno Biologijo, Inštitut za Biokemijo in Molekularno Genetiko, UL Medicinska fakulteta

The role of exosomes in glioblastoma immunosuppression

My name is Alja Zottel and I am postdoc researcher in prof. Komel lab at the Medical Centre for Molecular Biology, Institute of Biochemistry and Molecular Genetics, UL MF. I am working in the field of exosomes in glioblastoma, especially exosomes as a delivery system. Glioblastoma, the most common primary brain tumor, is one of the deadliest cancers. It is characterized by highly immunosuppressive nature that significantly contributes to the malignancy of the disease. Therefore, I was excited to read more about the role of exosomes in glioblastoma immunosuppression in the manuscript by Azambuja et al., recently published in Neuro-Oncology Advances (https://doi.org/10.1093/noajnl/vdaa056).

The authors showed that exosomes carry several inhibitory proteins, such as FasL, TRAIL, CTLA-4, CD39 and CD73. In vitro, exosomes suppressed the activity of different immune cells and were able to polarize M1 macrophages towards immunosuppressive M2 phenotype by modulating NF-κB pathway. The scientists also examined the effect of exosomes in vivo and showed they decreased the number of M1 macrophages and increased the number of M2 macrophages in mice. The results overall illustrate that glioblastoma-derived exosomes stimulate immunosuppression of the tumor.

By Alja Zottel.

ISEV2021 Annual Meeting

All are invited to attend ISEV2021 Annual Meeting, which will happen virtually from 18th-21st May 2021. Sessions and topics of the Meeting include: EV biomarkers; EV-based therapeutics; EVs of specific cells, organs, diseases, and organisms; Fundamental biology and function of EVs; Technologies and Methods.

At the moment Late Breaking Submission site is opened and will close on March 1st 2021. More information: https://na.eventscloud.com/website/16865/abstracts-3/.
You can register for the Meeting here: https://na.eventscloud.com/website/16865/reginfo/. Early registration ends on March 11th 2021.

The Meeting will be accompanied by an Education Day, where lecturers present the overview of the chosen EV-subfield. This year’s topics of the Education Day include: Isolation & Characterization of EVs; Methodologies for studying EV biogenesis&fate; Specific Methodologies applied to biofluid and specific organisms; Therapeutic and diagnostic use of EVs. Education Day will take place on Wednesday 12th May. ISEV2021 Full Conference Attendees will have full access to Education Day, there is also a possibility to attend the Education Day only.

More information is available at the Meeting website: https://na.eventscloud.com/website/16865/home/.

ISEV Infectious Diseases Meeting

Infectious Diseases and Extracellular Vesicles: an ISEV Meeting will be held virtually January 25-28, 2021.
Sessions and topics include EVs and COVID-19, EVs and viruses, non-viral infectious diseases, and methods and technologies in the study of EVs in infectious diseases.

More information is available at the meeting website: https://www.isev.org/event/isevidmeeting.

SiN-EV meeting: Improving rigour and standardisation of extracellular vesicle clinical studies

When: Thursday, December 10th, 2020, 14.00-18.00 CET
Where: virtually, via Webex interface

You are kindly invited to attend the yearly meeting of the Slovenian network for extracellular vesicles SiN-EV on the topic: “Improving rigour and standardisation of extracellular vesicle clinical studies“.

In the first part (14-16.10h CET), international experts on extracellular vesicles will present their work: Kenneth W. Witwer, Gabriella Pocsfalvi, Alicia Llorente, Elena S. Martens-Uzunova, An Hendrix.

In the second part (16.30-18.00h CET), hands-on workshop on EV-TRACK database (https://evtrack.org/) will be organised, with a focus on how to submit your research and improve its impact and reach (PhD students and postdocs are especially invited).

The detailed program is attached. The language of the meeting is English.

The deadline for registration is Monday, December 7th, on the following link https://forms.gle/YHRNsZumwrCFGv3r5. Registration to only one or both parts of the meeting is possible. We will send the link to access the meeting and workshop to your e-mail one day before the event.