University of Ljubljana, Faculty of Medicine, Institute of Biochemistry and Molecular Genetics
Laboratory of SNPs and genetic analysis in gastric cancer
PI: Petra Hudler
Stomach adenocarcinoma is associated with non-specific symptoms which results in late diagnosis and poor survival. Hypergastrinemia occurs in patients with atrophic gastritis and plays a role in tumour development. We are interested in the effect of gastrointestinal hormone gastrin on EV composition and secretion from gastric (cancer) cell lines and their contribution to tumorigenesis.
Laboratory of Proteomics, nanobodies and glioblastoma targeting
PI: Radovan Komel
Laboratory of Proteomics, nanobodies and glioblastoma targeting focuses on research of nanobodies that target potential novel biomarkers of glioblastoma stem cells, as well as on the study of small extracellular vesicles and archaesosmes as prospective systems for the therapeutic delivery of nanobodies. Furthermore, the laboratory is also studying small extracellular vesicles as a source of potential glioblastoma biomarkers.
Molecular genetics of psychiatric disorders
PI: Alja Videtič Paska
Psychiatric disorders represent one of the leading disease and disability burdens worldwide. As psychiatrist do not have any objective measure for support of diagnosis, prognosis and treatment monitoring, the search for biomarkers in psychiatry represents important point. Therefore, research on extracellular vesicles could contribute to advancement of the neuroscientific understanding of molecular mechanisms of health and disease.